Sulfated-Tungstate-Catalyzed Synthesis of Ureas/Thioureas via Transamidation and Synthesis of Forchlorofenuron was written by Wagh, Ganesh D.;Pathare, Sagar P.;Akamanchi, Krishnacharya G.. And the article was included in ChemistrySelect in 2018.Application of 2387-23-7 This article mentions the following:
N, N’-Disubstituted ureas and thioureas were efficiently and expeditiously synthesized by transamidation reaction between unsubstituted or monosubstituted ureas/thioureas and amines under solvent-free condition using sulfated tungstate as a heterogeneous mild solid acid catalyst. This protocol offered several advantages such as wide substrate scope, providing both sym. and unsym. ureas and thioureas, solvent-free reaction, recyclability of the catalyst and a simple work-up procedure. Application of the methodol. was demonstrated through simple and one step synthesis of forchlorofenuron [1-(2-chloropyridine-4-yl)-3-phenylurea] (CPPU), an approved plant growth regulator. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Application of 2387-23-7).
1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application of 2387-23-7
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics