Ascher, K. R. S. et al. published their research in Rivista di Parassitologia in 1963 | CAS: 383-31-3

4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Reference of 383-31-3

N,N-Dialkyl-p-halobenzenesulfonamides: their insecticidal properties and joint action with DDT was written by Ascher, K. R. S.. And the article was included in Rivista di Parassitologia in 1963.Reference of 383-31-3 This article mentions the following:

A series of para substituted N,N-dialkylbenzenesulfonamides (I) was tested as to their inherent toxicity and their joint action with DDT on resistant and susceptible housefly (Musca domestica vicina) strains. The most toxic compounds on tarsal contact were p-chloro and p-fluoro substituted with maximum potency in the N,N-di-Pr derivatives Knockdown was higher at 28-29° than at 24°. Toxicity was greater for the normal than for the resistant strain. Tests of the gaseous phase action showed the F compounds had better fumigant action than the resp. Cl compounds No synergism was found when I compounds combined with DDT were used on normal flies. Synergism was evident in the Cl series, especially the N,N-di-Et derivative, on the resistant strain. Synergism was also obtained using DDE which indicated that the synergism was a support effect for the toxic action of the substituted benzenesulfonamides. 48 references. In the experiment, the researchers used many compounds, for example, 4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3Reference of 383-31-3).

4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Reference of 383-31-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics