Chemo- and Regioselective Anionic Fries Rearrangement Promoted by Lithium Amides under Aerobic Conditions in Sustainable Reaction Media was written by Ghinato, Simone;De Nardi, Federica;Bolzoni, Paola;Antenucci, Achille;Blangetti, Marco;Prandi, Cristina. And the article was included in Chemistry – A European Journal in 2022.Recommanded Product: 19311-91-2 This article mentions the following:
A straightforward and efficient protocol to promote the metalation/anionic Fries rearrangements of O-aryl carbamates, using for the first time a lithium amide as metalating agent under aerobic/ambient-friendly reaction conditions, was reported. This approach enabled the sustainable preparation of salicylamide derivatives such as I [R = Et, i-Pr; R1 = H, 5-MeO, 3-Ph, etc.] with high levels of chemoselectivity within ultrafast reaction times, working at room temperature in the presence of air/moisture, and using environmentally responsible cyclopentyl Me ether as a solvent. Furthermore, the regioselective manipulation of O-2-tolyl carbamates had been accomplished using interchangeably alkyllithiums or lithium amides, with an unexpected beneficial contribution from the employment of biorenewable protic eutectic mixtures as non-innocent reaction media. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Recommanded Product: 19311-91-2).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Recommanded Product: 19311-91-2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics