N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Safety of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide
Design and synthesis of α-glucosidase inhibitor having DNA cleaving activity was written by Hakamata, Wataru;Yamamoto, Emiko;Muroi, Makoto;Mochizuki, Masataka;Kurihara, Masaaki;Okuda, Haruhiro;Fukuhara, Kiyoshi. And the article was included in Journal of Applied Glycoscience in 2006.Safety of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide This article mentions the following:
Apoptosis, or programmed cell death, is a mechanism by which cells undergo death to control cell proliferation or in response to DNA damage. The present study was designed to explore small mol. apoptosis inducers for antitumor agents. The synthesis of 4-sulfonylphenyl α-D-glucopyranoside derivatives 1-6 and 4-(sulfonylamino)phenyl α-D-glucopyranoside derivatives 7-12, endoplasmic reticulum (ER)-targeted small mols. that were designed to induce apoptosis from ER stress by ER glucosidase inhibition and DNA damage is described. Compounds 6 and 12, with a terminal 2-naphthyl group, indicated inhibitions of α-glucosidases from S. cerevisiae (IC50 = 51.7 μM and IC50 = 74.1 μM) and B. stearothermophilus (IC50 = 60.1 μM and IC50 = 89.1 μM). Moreover, compound 12 strongly induced the DNA strand breakage condition. When compounds 1-12 were assayed for their ability to inhibit processing by glucosidases at the cellular level, no effects on glycoprotein processing were observed In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Safety of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide).
N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Safety of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics