Komatsuda, Masaaki et al. published their research in Organic Letters in 2022 | CAS: 116332-61-7

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Synthetic Route of C10H10F3NO2

Ring-Opening Fluorination of Isoxazoles was written by Komatsuda, Masaaki;Ohki, Hugo;Kondo, Hiroki Jr.;Suto, Ayane;Yamaguchi, Junichiro. And the article was included in Organic Letters in 2022.Synthetic Route of C10H10F3NO2 This article mentions the following:

A series of tertiary fluorinated carbonyls I [R1 = Ph, 2-naphthyl, 2-thienyl, etc.; R2 = Me, nBu, (CH2)2Ph, etc.] was developed via ring-opening fluorination of isoxazoles by using an electrophilic fluorinating agent (Selectfluor) followed by deprotonation. This method featured mild reaction conditions, good functional group tolerance and a simple exptl. procedure. Diverse transformations of the resulting α-fluorocyanoketones were also demonstrated, furnished a variety of fluorinated compounds In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Synthetic Route of C10H10F3NO2).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Synthetic Route of C10H10F3NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics