Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors was written by Lee, Ki-Ho;Park, Chun-Eung;Min, Kyung-Hyun;Shin, Yong-Je;Chung, Coo-Min;Kim, Hui-Ho;Yoon, Hae-Jeoung;Won-Kim;Ryu, Eun-Ju;Shin, Yu-Jin;Nam, Hyun-Sik;Cho, Jeong-Woo;Lee, Hee-Yoon. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Synthetic Route of C10H10F3NO2 This article mentions the following:
A series of 3-aryl-3-azolylpropan-1-amines were prepared and screened for their capability of inhibiting monoamine reuptake. Analogs with nanomolar potency, good human in vitro microsomal stability, and low drug-drug interaction potential were described. In vivo models were used to evaluate I for antidepressive, anxiolytic, and analgesic activity. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Synthetic Route of C10H10F3NO2).
N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Synthetic Route of C10H10F3NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics