Synthesis of various acylating agents directly from carboxylic acids was written by Pilathottathil, Fathima;Vineet Kumar, Doppalapudi;Kaliyamoorthy, Alagiri. And the article was included in Synthetic Communications in 2020.Recommanded Product: 192436-83-2 This article mentions the following:
A straightforward synthesis of acylating reagents such as Weinreb and MAP amides from aromatic, aliphatic carboxylic acids, and amino acids using PPh3/NBS combination was described. A chemoselective modification of the carboxylic acid group into Weinreb amide in the presence of more reactive aldehydes and ketones was presented. All reactions were performed at ambient temperature under air using undried com. grade solvent. Furthermore, the present methodol. could be performed at a gram scale under inert-free reaction conditions. In addition, 7-azaindoline amide auxiliary (used for catalytic asym. aldol- and Mannich-type reactions), which behaves like Weinreb amide is also synthesized under similar reaction conditions. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Recommanded Product: 192436-83-2).
4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Recommanded Product: 192436-83-2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics