Pharmacological research on new salicylic and gentisic acid derivatives. III. Influences on pressure and respiration was written by Preziosi, P.;Reduzzi, F.. And the article was included in Archivio Italiano di Scienze Farmacologiche in 1955.Application In Synthesis of N,N-Diethylsalicylamide This article mentions the following:
Only doses above the therapeutic ones caused some transient hypotensive effect (more intense by doses of more than 50 mg./kg.): there was also a connection between the chem. constitution of the drug and the hypotensive effect, as for toxicity. N-diethylsalicylamide caused hypertension after a transient hypotension. As to respiration, diacetylgentisic acid and o-diethylaminoethoxybenzamide caused an increase of the amplitude, and salicoyl hydrazide and salicylamide, at higher doses, its decrease; N-diethylsalicylamide (from 30 mg./kg.) increased the respiratory frequency. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Application In Synthesis of N,N-Diethylsalicylamide).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Application In Synthesis of N,N-Diethylsalicylamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics