Hydrosilane-Assisted Synthesis of Urea Derivatives from CO2 and Amines was written by Zhao, Yulei;Guo, Xuqiang;Si, Zhiyao;Hu, Yanan;Sun, Ying;Liu, Yunlin;Ji, Zhongyin;You, Jinmao. And the article was included in Journal of Organic Chemistry in 2020.Quality Control of 1,3-Dicyclohexylurea This article mentions the following:
A methodol. employing CO2, amines, and phenylsilane was discussed to access aryl- or alkyl-substituted urea derivatives This procedure was characterized by adopting hydrosilane to promote the formation of ureas directly, without the need to prepare silylamines in advance. Control reactions suggested that FeCl3 was a favorable additive for the generation of ureas, and this 1,5,7-triazabicyclo[4.4.0]dec-5-ene-catalyzed reaction might proceed through nucleophilic addition, silicon migration, and the subsequent formal substitution of silylcarbamate. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Quality Control of 1,3-Dicyclohexylurea).
1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Quality Control of 1,3-Dicyclohexylurea
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics