Parallel synthesis of 1,2,3-thiadiazoles employing a “Catch and Release” strategy was written by Hu, Yonghan;Baudart, Sylvie;Porco, John A. Jr.. And the article was included in Journal of Organic Chemistry in 1999.COA of Formula: C9H10BrNO2 This article mentions the following:
A very efficient hybrid solution-/solid phase sequence for the synthesis of 1,2,3-thiadiazoles employing “resin capture” of ketones without the need for chromatog. was developed. Cyclative cleavage of resin-bound sulfonylhydrazones was accomplished using thionyl chloride to afford 1,2,3-thiadiazoles. Stille coupling of resin-bound intermediates was also demonstrated. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2COA of Formula: C9H10BrNO2).
4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.COA of Formula: C9H10BrNO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics