Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors was written by Kishore Kumar, G. D.;Chavarria, Gustavo E.;Charlton-Sevcik, Amanda K.;Arispe, Wara M.;MacDonough, Matthew T.;Strecker, Tracy E.;Chen, Shen-En;Siim, Bronwyn G.;Chaplin, David J.;Trawick, Mary Lynn;Pinney, Kevin G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.COA of Formula: C10H10F3NO2 This article mentions the following:
A small library of 36 functionalized benzophenone thiosemicarbazone analogs was prepared by chem. synthesis and evaluated for their ability to inhibit the cysteine proteases cathepsin L and cathepsin B. The six most active inhibitors of cathepsin L (IC50 < 85 nM) in this series were I (R = 2-F, 3-F3C, 4-F, 2,3-F2, 3,5-F2, 2,3,4,5-F4). These six analogs were selective for their inhibition of cathepsin L vs. cathepsin B (IC50 > 10,000 nM). The most active analog in the series, thiosemicarbazone I (R = 2-F), also efficiently inhibited cell invasion of the DU-145 human prostate cancer cell line. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7COA of Formula: C10H10F3NO2).
N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.COA of Formula: C10H10F3NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics