La Regina, Giuseppe et al. published their research in Journal of Medicinal Chemistry in 2015 | CAS: 192436-83-2

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Synthetic Route of C9H10BrNO2

Discovery of 1,1′-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors was written by La Regina, Giuseppe;Coluccia, Antonio;Famiglini, Valeria;Pelliccia, Sveva;Monti, Ludovica;Vullo, Daniela;Nuti, Elisa;Alterio, Vincenzo;De Simone, Giuseppina;Monti, Simona Maria;Pan, Peiwen;Parkkila, Seppo;Supuran, Claudiu T.;Rossello, Armando;Silvestri, Romano. And the article was included in Journal of Medicinal Chemistry in 2015.Synthetic Route of C9H10BrNO2 This article mentions the following:

New 1,1′-biphenylsulfonamides were synthesized and evaluated as inhibitors of the ubiquitous human carbonic anhydrase isoforms I, II, IX, XII, and XIV using acetazolamide (AAZ) as reference compound The 1,1′-biphenylsulfonamides inhibited all the isoforms, with Ki values in the nanomolar range of concentration, and were superior to AAZ against all of them. X-ray crystallog. and mol. modeling studies on the adducts that compound I, the most potent hCA XIV inhibitor of the series (Ki = 0.26 nM), formed with the five hCAs, provided insight into the mol. determinants responsible for the high affinity of this mol. toward the target enzymes. The results pave the way to the development of 1,1′-biphenylsulfonamides as a new class of highly potent hCA XIV inhibitors. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Synthetic Route of C9H10BrNO2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Synthetic Route of C9H10BrNO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics