A powerful reagent for synthesis of Weinreb amides directly from carboxylic acids was written by Niu, Teng;Zhang, Weiming;Huang, Danfeng;Xu, Changming;Wang, Haifeng;Hu, Yulai. And the article was included in Organic Letters in 2009.Quality Control of N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide This article mentions the following:
A powerful reagent, P[NCH3(OCH3)]3, for conversion of carboxylic acids directly to Weinreb amides was developed. In most cases the yields of the corresponding Weinreb amides were above 90% when P[NCH3(OCH3)]3 was heated with aromatic and aliphatic carboxylic acids in toluene. The sterically hindered carboxylic acids can also give the corresponding Weinreb amides in excellent yields. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Quality Control of N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide).
N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Quality Control of N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics