Hydrophobic Pockets of HPMC Enable Extremely Short Reaction Times in Water was written by Petkova, Desislava;Borlinghaus, Niginia;Sharma, Sudripet;Kaschel, Johannes;Lindner, Tanja;Klee, Johanna;Jolit, Anais;Haller, Vanessa;Heitz, Stephanie;Britze, Katarina;Dietrich, Justin;Braje, Wilfried M.;Handa, Sachin. And the article was included in ACS Sustainable Chemistry & Engineering in 2020.COA of Formula: C9H10BrNO2 This article mentions the following:
A methodol. for formation of ligated ultrasmall in-situ generated Pd nanoparticles in the hydrophobic pockets of benign cellulose derivative hydroxypropyl methylcellulose (HPMC) for chem. reactions to proceed very fast in water under mild reaction conditions was reported. Unprecedented short reaction times were exemplified for the Buchwald-Hartwig amination reaction of aryl bromides and aryl amines using in-situ generated Pd nanoparticles in aqueous HMPC solution to afford substituted aryl amines RNHR1 [R = 1-naphthyl, 3-MeC6H4, 2-MeOC6H4, etc.; R1 = Ph, 4-MeC6H4, 1-naphthyl, etc.]. In addition, very short reaction times were also demonstrated for the peptide coupling of carboxylic acids and amines using in-situ generated Pd nanoparticles in aqueous HMPC solution to afford aryl amides R2C(O)NR3R4 [R2 = Bn, 4-ClC6H4, 4-BrC6H4, etc.; R3 = OMe, n-hexyl, 3,5-(Me)2C6H3, etc.; R4 = H, Me, etc.]. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2COA of Formula: C9H10BrNO2).
4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.COA of Formula: C9H10BrNO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics