Salt induced micellar growth in aqueous solutions of a star block copolymer Tetronic 1304: Investigating the role in solubilizing, release and cytotoxicity of model drugs was written by Pillai, Sadafara A.;Sheth, Urjita;Bahadur, Anita;Aswal, Vinod K.;Bahadur, Pratap. And the article was included in Journal of Molecular Liquids in 2016.Quality Control of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) This article mentions the following:
Self-assembly of a com. available ethylene oxide-propylene oxide (EO-PO) star block copolymer, Tetronic1304 (T1304), in water and aqueous salt solutions was scrutinized using 1H NMR, viscosity, cloud point (CP), small angle neutron scattering (SANS) and dynamic light scattering (DLS). Solubilization of a hydrophobic oil dye (Orange-OT) and two poorly water soluble anticancer drugs quercetin (QN) and curcumin (CN) was examined The invitro drug release and cell viability of drugs were also assessed. T1304 being highly surface active, forms micelles (Dh = 12.3 nm and Nagg = 33) at low concentration and at ambient temperature Micellar growth and enhanced solubilization was observed in the presence of salt. The invitro release profiles of drugs from T1304 micelles evaluated from different kinetic models suggest controlled release of the drugs. The salt modulated core-shell micelles significantly enhance drug solubilization and cytotoxicity and thus improvise their usefulness for drug delivery systems. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Quality Control of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)).
N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Quality Control of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics