Oxidative Catalytic Spiroketalization Leading to Diastereoselective Synthesis of Spiro[benzofuran-2,1′-isochromene]s was written by Qiu, Jiang-Kai;Hao, Wen-Juan;Li, Guigen;Jiang, Bo. And the article was included in Advanced Synthesis & Catalysis in 2018.Application of 1146-43-6 This article mentions the following:
One-pot, two-step silver-catalyzed spiroketalization of the in-situ generated quinone imine ketals (QIKs) with β-alkynyl ketones was established, enabling multiple C-O and C-C bond-forming reactions to access densely functionalized spiro[benzofuran-2,1′-isochromene] derivatives with generally good yields. The use of β-alkynyl ketones bearing alkyl and aryl groups located at the α-position of the carbonyl group led to highly diastereoselective spiro[chromane-2,1′-isochromene] derivatives The reaction featured broad substrate scope, mild oxidative catalytic conditions and excellent diastereoselectivity. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Application of 1146-43-6).
N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Application of 1146-43-6
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics