Metabolic activation of procarbazine was written by Weinkam, R. J.;Shiba, D. A.. And the article was included in Life Sciences in 1978.COA of Formula: C11H13NO2 This article mentions the following:
NSC-77213 (procarbazine-HCl)(I) [366-70-1] chem. degradation and rat in vitro and in vivo, metabolism were investigated. I was rapidly oxidized to the azo derivative in aqueous solution in the presence of O. In vitro rat liver supernatant and microsomal preparations oxidized the azo function to azoxy isomers and further hydroxylated these metabolites in a manner that may be analogous to 1,2-dimethylhydrazine metabolism The hydroxylated metabolites are activated species that chem. react to give methylating and alkylating agents. An addnl. metabolic pathway was observed in vivo. Thus, I may be converted to free radical intermediates that decompose to give methane [74-82-8] and N-isopropyl-p-toluamide [2144-17-4]. I metabolites were separated and identified using high-performance liquid chromatog. and direct probe chem. ionization mass spectrometry. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0COA of Formula: C11H13NO2).
4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.COA of Formula: C11H13NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics