The synthesis and SAR of novel diaryl sulfone 11β-HSD1 inhibitors was written by Yan, Xuelei;Wang, Zhulun;Sudom, Athena;Cardozo, Mario;DeGraffenreid, Michael;Di, Yongmei;Fan, Pingchen;He, Xiao;Jaen, Juan C.;Labelle, Marc;Liu, Jinsong;Ma, Ji;McMinn, Dustin;Miao, Shichang;Sun, Daqing;Tang, Liang;Tu, Hua;Ursu, Stefania;Walker, Nigel;Ye, Qiuping;Powers, Jay P.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Safety of 3,4-Dichlorobenzamide This article mentions the following:
Human 11β-hydroxy steroid dehydrogenase type 1 (11β-HSD1) inhibitory activities of a novel series of diaryl sulfones are described. Optimization of this series resulted in several highly potent 11β-HSD1 inhibitors with excellent pharmacokinetic properties. I showed excellent efficacy in a non-human primate ex vivo pharmacodynamic model. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Safety of 3,4-Dichlorobenzamide).
3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Safety of 3,4-Dichlorobenzamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics