Evaluation of the toxicity and teratogenicity of drugs was written by Gastol-Lewinska, Lidia. And the article was included in Polish Journal of Pharmacology and Pharmacy in 1973.Formula: C20H20N8Na2O5 This article mentions the following:
Amethopterin Na (I Na salt) [7413-34-5] (0.001 mg/egg) was highly embryotoxic; allobarbital [52-43-7] (0.5 mg/egg), phenobarbital Na [57-30-7] (0.5 mg/egg), tolbutamide [64-77-7] (1.0 mg/egg), and insulin [9004-10-8] (1 IU) were slightly embryotoxic; and barbital Na [144-02-5] was not embryotoxic for White Leghorn chicken embryos between 50-56 hr of incubation. Allobarbital, phenobarbital and insulin produced malformations, but amethopterin, barbital, and tolbutamide were not teratogenic for chickens. In the experiment, the researchers used many compounds, for example, Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5Formula: C20H20N8Na2O5).
Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Formula: C20H20N8Na2O5
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics