Design, synthesis, and biological evaluation of aryl N-methoxyamide derivatives as GPR119 agonists was written by Jang, Yoon Kyung;Lee, Kyu Myung;Jung, Kwan-Young;Kang, Seung Kyu;Pagire, Suvarna H.;Lee, Jun Mi;Pagire, Haushabhau S.;Kim, Kwang Rok;Bae, Myung Ae;Lee, Hohjai;Rhee, Sang Dal;Ahn, Jin Hee. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Recommanded Product: 192436-83-2 This article mentions the following:
A series of N-methoxyamide derivatives was identified and evaluated as GPR119 agonists. Several N-methoxyamides with thienopyrimidine and pyridine scaffolds showed potent GPR119 agonistic activities. Among them, compound I displayed good in vitro activity and potency. Moreover, compound I lowered glucose excursion in mice in an oral glucose tolerance test and increased GLP-1 secretion in intestinal cells. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Recommanded Product: 192436-83-2).
4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 192436-83-2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics