Conformation and stereodynamics of ortho-hydroxy and ring-unsubstituted N,N-dialkylbenzamides was written by Jennings, W. Brian;Randall, David;Saket, Barahman Movassagh. And the article was included in Journal of the Chemical Society, Chemical Communications in 1982.Computed Properties of C11H15NO2 This article mentions the following:
Low temperature NMR spectral study of o-RC6H4CONR12 (R = OH, R1 = CHMe2, Et, CH2Ph; R = H, NR12 = 3,5-dimethylpiperidino) showed these compounds to have a noncoplanar conformation with barriers of 7-9 kcal/mol to rotation about the aryl-CO bond. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Computed Properties of C11H15NO2).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Computed Properties of C11H15NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics