Synthesis and geometric configuration of 2-(hydroxyiminomethyl)thiazole-4-carboxylic acid in antibiotic althiomycin was written by Shiba, Tetsuo;Inami, Kaoru;Sawada, Kozo;Hirotsu, Yoshihiro. And the article was included in Heterocycles in 1979.Product Details of 61189-99-9 This article mentions the following:
Isomeric oximes I (R = Et) were prepared from (EtO)2CHCO2Et in 6 steps. The isomers were separated and their configuration determined by nuclear Overhauser enhancement. These assignments were used to established that I (R = H) in althiomycin have the syn configuration and it isomerized on purification on acid ion exchange resin. Althiomycin has the syn configuration II. In the experiment, the researchers used many compounds, for example, 2,2-Diethoxyacetamide (cas: 61189-99-9Product Details of 61189-99-9).
2,2-Diethoxyacetamide (cas: 61189-99-9) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Product Details of 61189-99-9
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics