Cleavage of the C-C triple bond of ketoalkynes: synthesis of 4(3H)-quinazolinones was written by Yang, Xifa;Cheng, Guolin;Shen, Jinhai;Kuai, Changsheng;Cui, Xiuling. And the article was included in Organic Chemistry Frontiers in 2015.Category: amides-buliding-blocks This article mentions the following:
A novel protocol for the synthesis of 4(3H)-quinazolinones I (R1 = H, 6-Me, 7-Me, 5-F, etc.; R2 = H, n-hexyl, Ph, 2-MeC6H4, 2-thienyl, etc.; R3 = H, Me, Ph) from o-amino benzamides II and alkynyl ketones R2CCC(O)Ph under oxidant-, metal-, and ligand-free conditions has been developed. The process includes selective cleavage of the C-C triple bond of alkynyl ketones and formation of two C-N bonds. In the experiment, the researchers used many compounds, for example, 6-Chloro-2-aminobenzamide (cas: 54166-95-9Category: amides-buliding-blocks).
6-Chloro-2-aminobenzamide (cas: 54166-95-9) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics