Zhang, Weikang et al. published their research in Advanced Synthesis & Catalysis in 2018 | CAS: 119023-25-5

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Category: amides-buliding-blocks

Auto-Tandem Catalysis with Ruthenium: From o-Aminobenzamides and Allylic Alcohols to Quinazolinones via Redox Isomerization/Acceptorless Dehydrogenation was written by Zhang, Weikang;Meng, Chong;Liu, Yan;Tang, Yawen;Li, Feng. And the article was included in Advanced Synthesis & Catalysis in 2018.Category: amides-buliding-blocks This article mentions the following:

A strategy for the synthesis of quinazolinones I [R = H, 7-Me, 6,8-di-Cl, etc.; R1 = Et, i-Pr, n-Bu, etc.; R2 = H, n-Bu, Bn] was proposed via Ru-catalyzed redox isomerization/acceptorless dehydrogenation of o-aminobenzamides with allylic alcs. and was obtained in moderate to high yields. This strategy was attractive due to high atom efficiency, minimal consumption of chems. and energy. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5Category: amides-buliding-blocks).

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics