Green Catalyst- and Additive-Free Three-Component Deamination Cyclization Synthesis of 3-Substituted-4- oxo-2-quinazolinonyl Sulfides was written by Zheng, Lvyin;Xie, Zhen;Cai, Liuhuan;Liu, Gongping;Mei, Weijie;Zou, Xiaoying;Zhuo, Xiaoya;Fan, Xiaolin;Guo, Wei. And the article was included in ChemistrySelect in 2021.Product Details of 119023-25-5 This article mentions the following:
An efficient three-component deamination annulation of 2-aminobenzamides 2-NH2-RC6H4C(O)NH2 (R = H, 3-Me, 4-F, 5-Cl, etc.), isothiocyanates R1NCS (R1 = Ph, Bn, Me, etc.) and alkyl bromides R2R3CHBr (R2 = ethoxycarbonyl, benzyloxycarbonyl, Ph, etc.; R3 = H, Et, Pr, Bu, phenyl) for the synthesis of valuable 3-substituted-4-oxo-2-quinazolinonyl sulfides I (R4 = H, 6-Me, 7-Cl, 8-Br, etc.) is reported. The reaction proceeds in the absence of any external catalysts and additives. The facile process has the advantages of broad substrate scopes, mild reaction conditions and environmental friendliness, which might provide the synthetic applications for 3-substituted-4-oxo-2-quinazolinonyl sulfides I as potential anti-cancer agents in medicinal chem. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5Product Details of 119023-25-5).
2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Product Details of 119023-25-5
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics