Month: January 2023

Copper(II)-Catalyzed Enantioselective Intramolecular Carboamination of Alkenes was written by Zeng, Wei;Chemler, Sherry R.. And the article was included in Journal of the American Chemical Society in 2007.HPLC of Formula: 19311-91-2 This article mentions the following:

The enantioselective oxidative cyclizations of γ-alkenyl arenesulfonamides, e.g. I [R¹ = H, Me, Ph; R¹₂ = (CH₂)₄, (CH₂)₅; R² = H, Me, Cl, MeO], and a δ-alkenyl arylsulfonamide for the synthesis of nitrogen heterocycles are presented. The reactions are catalyzed by chiral copper(II) complexes, and MnO₂ is used as the inexpensive stoichiometric oxidant. A variety of five-membered heterocycles, e.g. II, and a tetrahydroisoquinoline have been synthesized in good to excellent yields with good to excellent levels of enantioselectivity. This is the first reported copper-catalyzed enantioselective carboamination of alkenes. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2HPLC of Formula: 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.HPLC of Formula: 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Stereoselective sulfoxide directed reduction of 1,2-diketo-derivatives to enantiomerically pure syn and anti 1,2-diols: correction of the relative configuration by X-ray and chemical correlation to goniobutenolides A and B was written by Solladie, Guy;Hanquet, Gilles;Rolland, Catherine. And the article was included in Tetrahedron Letters in 1999.COA of Formula: C6H12N2O4 This article mentions the following:

In a report [G. Solladie; 1997] on the enantioselective synthesis of syn and anti 1,2-diols from oxalyldi(N-methyl-N-methoxyamide), a sample inversion for ¹³C NMR anal. led to an incorrect attribution of relative configurations. Correction of the configurations of these diols, I and II (R = Me, Ph, allyl, CH:CH₂), was made by x-ray anal. and chem. correlation to two known natural products, goniobutenolides A and B. Thus, the relative configuration of diols obtained by stereoselective sulfoxide directed reduction of β-hydroxy-γ-keto sulfoxides of type III is erythro with DIBAL-H or DIBAL-H/Yb(O₂CCF₃)₃ and threo with DIBAL-H/ZnI₂. In the experiment, the researchers used many compounds, for example, N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1COA of Formula: C6H12N2O4).

N1,N2-Dimethoxy-N1,N2-dimethyloxalamide (cas: 106675-70-1) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.COA of Formula: C6H12N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Effect of plasticizers on the properties of polycaprolactam was written by Poludennaya, V. M.;Volkova, N. S.;Arkhangel’skii, D. N.;Konkin, A. A.. And the article was included in Khimicheskie Volokna in 1969.Reference of 5339-69-5 This article mentions the following:

High-mol.-weight polycaprolactam (I) gives stronger cord, but it has increased viscosity (η) and presents difficulties in spinning. The addition of ≤20% PhSO2NHPr-iso, p-EtC6H4SO2NHPr-iso, or 2,4-Et2C6H3SO2NHPr-iso to ε-caprolactam, prior to the polymerization, decreased η of I melt without decreasing its mol. weight Thus I of mol. weight 30,000 without the plasticizer had η = 11,000 poises; the addition of 5-7% plasticizer decreased η to 6000-5000 poises, which is sufficient for spinning I melt in standard equipment. In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Reference of 5339-69-5).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Reference of 5339-69-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Effective wall slip in chutes and channels: experiments and discrete element simulations was written by Artoni, Riccardo;Santomaso, Andrea. And the article was included in Granular Matter in 2014.Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) This article mentions the following:

Wall slip is an important phenomenon for the flow of granular materials in chutes and channels. The appearance of a slip velocity at the wall critically affects wall stresses and flow profiles, and particularly the total flowrate. In this work we show, through numerical simulations and experiments, that the global slip phenomenon at a wall has peculiar features which deviate significantly from simple sliding behavior. At first we present exptl. data for the vertical chute flow which highlight that wall slip depends on many operating and system variables such as flow rate, material properties, wall properties. Secondly, we resume a large campaign of numerical data performed in 2D with polygonal particles, and try to analyze the effect of material properties, contact parameters, operating variables, different flow configurations, on the slip phenomenon. The numerical campaign allowed to identify the main parameters affecting the wall slip behavior of a numerical model of granular flow, providing the ingredients for the creation of a framework for the description of wall slip. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Low temperature peroxide bleaching of cotton fabric activated with monoacetyl guanidine was written by Wang, Hong;Cao, Ji-liang. And the article was included in Yinran in 2011.Product Details of 10543-57-4 This article mentions the following:

Bleaching of cotton fabric is carried out with hydrogen peroxide/acetylguanidine (ACG) activation system. Factors of activator types, ACG dosage, bleaching temperature and time as well as pH value on bleaching effects are investigated, and compared to those with hydrogen peroxide or hydrogen peroxide/tetraacetylethylenediamine (TAED) systems. Results show that cotton fabric treated at 60 °C for 60 min with hydrogen peroxide (30%) 3 g/L, ACG 1.6 g/L, pH value about 8, features high whiteness. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Product Details of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Product Details of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lithiation of a silyl ether: Formation of an ortho-Fries hydroxy ketone was written by Lo, Hong-Jay;Lin, Chin-Yin;Tseng, Mei-Chun;Chein, Rong-Jie. And the article was included in Angewandte Chemie, International Edition in 2014.COA of Formula: C11H15NO2 This article mentions the following:

A hydroxy-directed alkylation of an N,N-di-Et aryl amide using CIPE-assisted α-silyl carbanions (CIPE = complex-induced proximity effect) was developed using a simple reagent combination of LDA [LiN(CHMe₂)₂] and Me₃SiCl. A study on the mechanism, and the application of the procedure to an anionic Snieckus-Fries rearrangement for a highly efficient synthesis of the potent phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 are reported. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2COA of Formula: C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.COA of Formula: C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Finding a prospective dual-target drug for the treatment of coronavirus disease by theoretical study was written by Mahnam, Karim;Ghobadi, Zahra. And the article was included in Journal of Biomolecular Structure and Dynamics.Electric Literature of C18H17NO5 This article mentions the following:

Spike protein of coronavirus is a key protein in binding and entrance of virus to the human cell via binding to the receptor-binding domain (RBD) domain of S1 subunit to peptidase domain region of ACE2 receptor. In this study, the possible effect of 24 antiviral drugs on the RBD domain of spike protein was investigated via docking and mol. dynamics simulation for finding a dual-target drug. At first, all drugs were docked to the RBD domain of spike protein, and then all complexes and free RBD domains were sep. used for mol. dynamics simulation for 50 ns via amber18 software. The simulation results showed that 10 ligands from 28 ligands were separated from the RBD domain, and among 18 remained ligands, baloxavir marboxil, and danoprevir drugs, besides endonuclease activity and protease inhibitory, can bind to key residues of the RBD domain. Then these drugs have a dual target and should be more effective than current drugs, and exptl. studies should be done on baloxavir marboxil and danoprevir as more potential drugs for coronavirus disease. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Electric Literature of C18H17NO5).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Electric Literature of C18H17NO5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Enzymatic scouring and low-temperature bleaching of fabrics constructed from cotton, regenerated bamboo, poly(lactic acid), and soy protein fibers was written by Spicka, Nina;Zupin, Ziva;Kovac, Janez;Forte Tavcer, Petra Eva. And the article was included in Fibers and Polymers in 2015.Category: amides-buliding-blocks This article mentions the following:

In the present study, fabrics constructed from cotton, regenerated bamboo, poly(lactic acid), and soy protein fibers were scoured with pectinase enzymes, bleached with different bleaching processes using peracetic acid (PAA), and conventionally bleached with hydrogen peroxide (HP). The enzymic scouring and bleaching with PAA have been chosen in order to minimize fiber damage and to perform the processes in more benign conditions. PAA was added to the bleaching bath in the form of a com. solution or it was produced in situ in the presence of HP with the addition of a bleach activator, tetraacetylethylenediamine (TAED), or arylesterase enzymes. The conventional process was performed at 90° in highly alk. pH media, and the bleaching processes with PAA were performed at 65° in neutral to slightly alk. pH media. The results revealed that after the enzymic scouring, the hydrophilicity of the fabrics is adequate. Compared with the cotton fibers, the regenerated bamboo and especially the poly(lactic) acid and soy protein fibers are significantly damaged during conventional HP bleaching. By contrast, bleaching with PAA revealed a strong whitening ability that is comparable to that of conventional bleaching with HP but with substantially reduced fiber damage. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Category: amides-buliding-blocks).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

ZnEt₂ promoted hydrosilylation of CO₂ and formylation or urealation of amines with CO₂ as a C1 building block was written by Du, Chongyang;Chen, Yaofeng. And the article was included in Huaxue Xuebao in 2020.SDS of cas: 2387-23-7 This article mentions the following:

Fixation and transformation of CO₂ are of the great importance, especially the conversion of CO₂ into valuable organic compounds catalyzed by the cheap and biocompatible metal catalysts. Zinc is an abundant, biocompatible and environmentally friendly element. ZnEt₂ is com. available, and has been widely used as reducing or transmetalation agent in hydrocarboxylation of unsaturated hydrocarbons with CO₂. In these reactions, ZnEt₂ is generally used in stoichiometric amount or excess amount This manuscript reports the hydrosilylation of CO₂ into methoxysilane promoted by a catalytic amount of ZnEt₂ (1.0 mol%), the ZnEt₂ promoted formylation or urealation of amines with CO₂ as a one-carbon (C1) building block is also described. The hydrosilylation of CO₂ into methoxysilane (CH₃OSi(OEt)₃) with (EtO)₃SiH as a hydrosilylation reagent is affected by CO₂ pressure, ZnEt₂ amount, reaction temperature and reaction time. Under the reaction conditions of 1.0 MPa CO₂ (the initial CO₂ pressure) and 1.0 mol% ZnEt₂, the yield of methoxysilane is up to ca. 90% after 7 h at 90°C, and no solvent is used for this reaction. In the presence of organic amine, the reaction gives formamide or urea instead of methoxysilane. Under 1.5 MPa CO₂, 1.0 mol% ZnEt₂, 2.4 equivalent (EtO)₃SiH and 100°C, a series of secondary amines, both the aromatic ones and the aliphatic ones, can be formylated into formamides. In the formylation of N-methylanilines with different substituents at para-position, the isolated yields of the formylation products are in the order of OMe≈Me>H>F>Cl≈Br>CF₃>NO₂, indicating the electron-donating group at the para-position of the N-methylanilines is benefit for the formylation reaction. When primary amines are used as the substrates, the reactions prefer to produce urea derivatives under the same reaction conditions. In the urealation reaction, the electronic effect is not as significant as that in the formylation reaction. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7SDS of cas: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.SDS of cas: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Halogen-Lithium Exchange of Sensitive (Hetero)aromatic Halides under Barbier Conditions in a Continuous Flow Set-Up was written by Weidmann, Niels;Nishimura, Rodolfo H. V.;Harenberg, Johannes H.;Knochel, Paul. And the article was included in Synthesis in 2021.Application of 116332-61-7 This article mentions the following:

A halogen-lithium exchange reaction of (hetero)aromatic halides performed in the presence of various electrophiles such as aldehydes, ketones, Weinreb amides, and imines using BuLi as exchange reagent and a com. available flow set-up was reported. The organolithiums generated in-situ were instantaneously trapped with various electrophiles (Barbier conditions) resulted in the formation of polyfunctional (hetero)arenes. This method enabled the functionalization of (hetero)arenes containing highly sensitive functional groups such as esters, which were not tolerated in batch conditions. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Application of 116332-61-7).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Application of 116332-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics