Syntheses of stable-isotope labeled [M + 7] and [M + 6] 2-(methylamino)imidazole was written by Zhang, Yinsheng. And the article was included in Journal of Labelled Compounds & Radiopharmaceuticals in 2002.Name: 2,2-Diethoxyacetamide This article mentions the following:
Stable isotope-labeled 2-(methylamino)imidazole (M + 7 and M + 6) was required as an intermediate in the synthesis of mass labeled drug candidates. These two isotopomers were synthesized with total yields of 24 and 36%, resp. Labeled 2-aminoimidazole (M + 4) was prepared from labeled isothiourea (M + 3) and 2-aminoacetaldehyde di-Me acetal (M + 1 and M + 2). The (M + 1) version of 2-aminoacetaldehyde di-Me acetal was obtained in two steps starting with potassium [15N]phthalimide, while the (M + 2) version was prepared from the reduction of diethoxyacetamide with LiAlD4. Two different approaches for the preparation of 2-(methylamino)imidazole from 2-aminoimidazole were explored. Attempts to prepare protected 2-aminoimidazole to couple with CH3I (M + 4) to form the desired labeled 2-(methylamino)imidazole failed. However, methylation was achieved by applying N-formamidation followed by deutero-reduction These successful syntheses allowed us to selectively label with nitrogen, carbon or hydrogen isotopes at most of the positions of 2-(methylamino)imidazole. In the experiment, the researchers used many compounds, for example, 2,2-Diethoxyacetamide (cas: 61189-99-9Name: 2,2-Diethoxyacetamide).
2,2-Diethoxyacetamide (cas: 61189-99-9) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Name: 2,2-Diethoxyacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics