New methods for the synthesis of 2-arylpyrroles was written by Kruse, Chris G.;Bouw, Jan P.;Van Hes, Roelof;Van de Kuilen, Aalt;Den Hartog, Jack A. J.. And the article was included in Heterocycles in 1987.COA of Formula: C10H10F3NO2 This article mentions the following:
Two short and efficient synthetic approaches for 2-arylpyrroles I (R = Ph, 4-FC6H4, 2,6-F2C6H3, 4-F3CC6H4 etc.) are presented. The key intermediates RCOCH2CH2CHO are conveniently obtained from com. available RCOMe or benzoic acid derivatives RCOCl, RCONMeOMe. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7COA of Formula: C10H10F3NO2).
N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.COA of Formula: C10H10F3NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics