Month: February 2023

Synthesis of chidamide, a new histone deacetylase (HDAC) inhibitor was written by Yin, Zi-hui;Wu, Zhong-wen;Lan, YU-kun;Liao, Chen-zhong;Shan, Song;Li, Zhi-liang;Ning, Zhi-qiang;Lu, Xian-ping;Li, Zhi-bin. And the article was included in Zhongguo Xinyao Zazhi in 2004.Product Details of 119023-25-5 This article mentions the following:

Objective: To synthesize chidamide {N-(2-amino-5-fluorophenyl)-4-[N-(pyridin-3-ylacryloyl)aminomethyl]benzamide}, a new histone deacetylase (HDAC) inhibitor. Methods: 3-Pyridineacrylic acid was prepared from 3-pyridine carboxaldehyde by Knoevenagel reaction, which was converted to the title compound by 2 steps of acetylation in the presence of N,N’-carbonyldiimidazole. Results: Chidamide was synthesized in a total yield of 29%. Conclusion: A gentle and easily controlled process for synthesis of chidamide is worked out. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5Product Details of 119023-25-5).

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Product Details of 119023-25-5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Characterization and biological studies of bis- and tera-acetyl derivatives of hydrocarbon-bridged diamines-I was written by Haque, Naheed;Hussain, Izhar. And the article was included in Pakistan Journal of Pharmaceutical Sciences in 2013.Recommanded Product: N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) This article mentions the following:

A systematic study of the pharmaceutically important, double ended, chelating agents of the types CH₃CONH(CH₂)_nNHCOCH₃ and (CH₃CO)₂N(CH₂)_n N(COCH₃)₂, where n = 2, 3, 4, 5 and 6, prepared by the bis- and tetra-acetylation of the corresponding diamino-polymethylenes, have been carried out. Bis- and tetra-acetyl derivatives have been characterized by their elemental anal. and the FTIR spectra, Mass spectra and ¹H NMR spectra of these compounds have been reported to establish their structures. In the present work, FTIR spectra have been found an excellent means for distinguishing the bis-acetyl derivatives from their tetra-acetyl counterparts. The structures of these bis- and tetra-acetyl compounds have further been established by their ¹H NMR and Mass Spectra. The selective pharmacol. screening of the derivatives was carried out according to the standard procedures. The compounds were screened for their antibacterial and antifungal activities and it was found that majority of these compounds did not possess any remarkable activity. Only the compound BA1,2-DAE, showed significant antifungal activity against Microsporum canis (80%). In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Recommanded Product: N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Recommanded Product: N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Combining Theoretical and Data-Driven Approaches To Predict Drug Substance Hydrate Formation was written by Tilbury, Carl J.;Chen, Jie;Mattei, Alessandra;Chen, Shuang;Sheikh, Ahmad Y.. And the article was included in Crystal Growth & Design in 2018.HPLC of Formula: 53902-12-8 This article mentions the following:

Hydrates represent a very significant fraction of pharmaceutical mol. crystals and can be leveraged to simplify downstream processing for formulations such as wet granulation and hot-melt extrusion. In silico methods to predict hydrate formation can guide exptl. screening and evaluate residual risk of selected forms. Both solution mixing thermodn. and relative propensities of hydrogen bond formation can be used for virtual screening. Our study assessed these techniques for a previously studied set of relatively simple drug compounds (average mol. weight 300) and a new set of more complex AbbVie-pipeline compounds (average mol. weight 550). Although solution thermodn. have been shown to successfully discriminate hydrate formation for the set of smaller drug mols., this technique did not provide successful screening for the more complex set of AbbVie compounds tested. A single-differential hydrogen bond propensity (SD-HBP) score, which accounts for only the strongest donor-acceptor pairing in both anhydrate and hydrate forms, also provides little utility. We therefore developed a multi-differential hydrogen bond propensity (MD-HBP) score that considers the competitive effect of multiple donor-acceptor interactions in each form. Addnl., the MD-HBP score utilizes COSMO-RS theory to predict solid-state conformations, to strengthen the data-driven anal. of the solid-state and ensure more accurate description of possible hydrogen bond networks in anhydrate and hydrate solid forms. This quant. MD-HBP score performed well at differentiating between hydrate-forming and non-hydrate-forming compounds for both sets of compounds; thus, it can be applied more broadly in solid form development. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8HPLC of Formula: 53902-12-8).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.HPLC of Formula: 53902-12-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors was written by Yokoyama, Takeshi;Kashihara, Mirai;Mizuguchi, Mineyuki. And the article was included in Journal of Medicinal Chemistry in 2021.Formula: C18H17NO5 This article mentions the following:

Transthyretin (TTR) is a causative protein of TTR amyloidosis (ATTR amyloidosis), a general term for diseases characterized by deposition of TTR amyloid fibrils in specific organs. ATTR amyloidosis can be ameliorated by stabilization of the TTR tetramer through the binding of small mols. Here, we show that the clin. anthelmintic drugs bithionol (42) and triclabendazole (43) potently inhibit aggregation of the amyloidogenic variant V30M-TTR. A competitive binding assay using a fluorescence probe showed that the binding affinity of 42 with V30M-TTR was significantly higher than that of the first-in-class drug tafamidis (1), and the binding affinity of 43 was similar to that of 1. The crystallog. and thermodn. anal. revealed that 42 efficiently occupied the halogen-binding grooves of TTR, resulting in the favorable binding entropy. Multifaceted in vitro studies of anthelmintic drugs have the potential to reposition these drugs as ATTR amyloidosis inhibitors. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Formula: C18H17NO5).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Formula: C18H17NO5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fluoro-Substituted Methyllithium Chemistry: External Quenching Method Using Flow Microreactors was written by Colella, Marco;Tota, Arianna;Takahashi, Yusuke;Higuma, Ryosuke;Ishikawa, Susumu;Degennaro, Leonardo;Luisi, Renzo;Nagaki, Aiichiro. And the article was included in Angewandte Chemie, International Edition in 2020.Reference of 192436-83-2 This article mentions the following:

The external quenching method based on flow microreactors allows the generation and use of short-lived fluoro-substituted methyllithium reagents, such as fluoromethyllithium, fluoroiodomethyllithium, and fluoroiodostannylmethyllithium. Highly chemoselective reactions were developed, opening new opportunities in the synthesis of fluorinated mols. using fluorinated organometallics. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Reference of 192436-83-2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Reference of 192436-83-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Herbicides. IV. The synthesis of 2,6-dichlorobenzonitrile was written by Koopman, H.. And the article was included in Recueil des Travaux Chimiques des Pays-Bas in 1961.Recommanded Product: 6-Chloro-2-aminobenzamide This article mentions the following:

Four new methods were described for the synthesis of 2,6-dichlorobenzonitrile (I). Method A: 2,6-Dichloroaniline was diazotized and the diazonium compound converted by the (Sandmeyer) reaction into 75% I when the Sandmeyer catalyst was buffered with NaHCO₃. Method B: 2,3-Dichloronitrobenzene was treated with CuCN and pyridine to give 75% 2-chloro-6-nitrobenzonitrile, 120-2° (MeOH), which was reduced with iron in concentrated HCl-MeOH to give 89% 2-amino-6-chloro-benzonitrile, m. 136-8° (benzene). Sandmeyer reaction there gave 79% I. Iron reduction and partial saponification 2-chloro-6-nitrobenzonitrile gave 41% 2-amino-6-chlorobenzamide, m. 130-1°. Method C: 2,6-dichlorobenzaldehyde and HONHSO₃Na gave 99% anti-2,6-dichlorobenzaldoxime, m. 175-6° (benzene), which was dehydrated by refluxing with Ac₂O to 95% I. To prove the anti structure both the anti- and the syn-2,6-dichlorobenzaldoxime acetate were prepared, m. 80-5° and 43-6°, resp. Method D: By vapor phase reaction, 2,6-dichlorotoluene, excess ammonia, air, and N at 360° on Al₂O₃V₂O₅-catalyst gave 50% I. I strongly inhibited the germination of seeds and the growth of young plants. In the experiment, the researchers used many compounds, for example, 6-Chloro-2-aminobenzamide (cas: 54166-95-9Recommanded Product: 6-Chloro-2-aminobenzamide).

6-Chloro-2-aminobenzamide (cas: 54166-95-9) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 6-Chloro-2-aminobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The analgesic properties of some substituted salicylamide derivatives was written by Carron, M.;Tabart, J.;Jullien, Mrs.. And the article was included in Therapie in 1952.Related Products of 19311-91-2 This article mentions the following:

Derivatives of salicylamide (I) were prepared; they had general formulas C₆H₄OH.CONRR’ or C₆H₄CONH₂. OR”. Their lethal doses (per os) and analgesic effects were determined by the Armour and Smith method (J. Pharm. Exptl. Therap. 72, 74, 1941). Introduction of hydrosol. groups, methoxylation, and acetylation of the phenolic function lowered the analgesic power; ethoxylation of the same increased it. Substitution of amide H by alkyls activated the analgesic effect from Et to iso-Pr, but Me and Bu derivatives had low activities. Hydrosol. functions introduced on the amide did not modify the effect of the products. Joining 2 I mols by a C₃ chain increased its effect, but a C₁ or C₂ linkage lowered the activity of the compounds Min. analgesic doses and lethal doses of the most active derivatives compared with acetylsalicylic acid (II) were: I 0.3, 0.6; N-diethyl-I 0.15, 0.85; o-ethoxybenzamide 0.2, 0.7; o-acetylsalicylureide 0.2, 0.3; methylol-I 0.24, 0.85; N-isopropyl-I 0.25, 0.65; propylenebis-I 0.26, 0.95; and II 0.4, 0.83 g./kg. weight of mice. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Related Products of 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Novel applications of eureco RP 103 was written by Garaffa, Roberto;Warunek, Magda;Findlay, Paul;Pears, David;Scullion, Lisa;Hughes, Melanie. And the article was included in IP.com Journal in 2016.SDS of cas: 10543-57-4 This article mentions the following:

Eureco RP 103 is a new free flowing, boron free particle containing 6-phthalimidoperoxyhexanoic acid (PAP). The particle is stable on its own and when formulated with various other media under ambient and elevated temperature and humidity conditions. It is a versatile material that can be used in a wide range of different product formulations and applications. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4SDS of cas: 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.SDS of cas: 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Prediction of permeability across intestinal cell monolayers for 219 disparate chemicals using in vitro experimental coefficients in a pH gradient system and in silico analyses by trivariate linear regressions and machine learning was written by Kamiya, Yusuke;Omura, Asuka;Hayasaka, Riku;Saito, Rie;Sano, Izumi;Handa, Kentaro;Ohori, Junya;Kitajima, Masato;Shono, Fumiaki;Funatsu, Kimito;Yamazaki, Hiroshi. And the article was included in Biochemical Pharmacology (Amsterdam, Netherlands) in 2021.Related Products of 53902-12-8 This article mentions the following:

For medicines, the apparent membrane permeability coefficients (Papp) across human colorectal carcinoma cell line (Caco-2) monolayers under a pH gradient generally correlate with the fraction absorbed after oral intake. Furthermore, the in vitro Papp values of 29 industrial chems. were found to have an inverse association with their reported no-observed effect levels for hepatotoxicity in rats. In the current study, we expanded our influx permeability predictions for the 90 previously investigated chems. to both influx and efflux permeability predictions for 207 diverse primary compounds, along with those for 23 secondary compounds Trivariate linear regression anal. found that the observed influx and efflux logPapp values determined by in vitro experiments significantly correlated with mol. weights and the octanol-water distribution coefficients at apical and basal pH levels (pH 6.0 and 7.4, resp.) (apical to basal, r = 0.76, n = 198; and basal to apical, r = 0.77, n = 202); the distribution coefficients were estimated in silico. Further, prediction accuracy was enhanced by applying a light gradient boosting machine learning system (LightGBM) to estimate influx and efflux logPapp values that incorporated 17 and 19 in silico chem. descriptors (r = 0.83-0.84, p < 0.001). The determination in vitro and/or prediction in silico of permeability coefficients across intestinal cell monolayers of a diverse range of industrial chems./food components/medicines could contribute to the safety evaluations of oral intakes of general chems. in humans. Such new alternative methods could also reduce the need for animal testing during toxicity assessment. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Related Products of 53902-12-8).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Related Products of 53902-12-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A comparative study of several activator in enzyme peroxide one bath low temperature pretreatment was written by Zhu, Jun-ping. And the article was included in Yinran Zhuji in 2015.Application of 10543-57-4 This article mentions the following:

The application effect of four hydrogen peroxide activators in enzyme one bath pretreatment was investigated. The results showed that the effect of TAED was good. Enzyme peroxide one bath could reduce the alkali dosage and reduce the burden on sewage treatment. The application process was as follows: gray fabric padding the first working fluid (two-dip-two-nip, padding rate 90% ∼ 100%, the working fluid temperature 50 ∼ 55 °C) → curled batching (50 °C,12 h) → padding the second working fluid (two-dip-two-nip, padding rate 90% ∼ 100%, the working fluid temperature 40 °C) → steaming (80 °C,10 min) → washing → drying. The first working fluid: KDN scouring enzyme 2 g/L, low temperature scouring penetrant GR-01 10 g/L, hydrogen peroxide solution 36 mL/L, activator 18 g/L, pH = 8. The second working fluid: low temperature scouring penetrant GR-01 10 g/L, hydrogen peroxide solution 44 mL/L, activator 22 g/L, pH = 8 ∼ 9. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Application of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics