Liu, Jianjian published the artcileChalcogen bond-guided conformational isomerization enables catalytic dynamic kinetic resolution of sulfoxides, Related Products of amides-buliding-blocks, the main research area is chiral sulfoxide preparation enantioselective regioselective; sulfinyl dibenzaldehyde alc esterification.
Conformational isomerization can be guided by weak interactions such as chalcogen bonding (ChB) interactions. Here authors report a catalytic strategy for asym. access to chiral sulfoxides by employing conformational isomerization and chalcogen bonding interactions. The reaction involves a sulfoxide bearing two aldehyde moieties as the substrate that, according to structural anal. and DFT calculations, exists as a racemic mixture due to the presence of an intramol. chalcogen bond. This chalcogen bond formed between aldehyde (oxygen atom) and sulfoxide (sulfur atom), induces a conformational locking effect, thus making the sym. sulfoxide as a racemate. In the presence of N-heterocyclic carbene (NHC) as catalyst, the aldehyde moiety activated by the chalcogen bond selectively reacts with an alc. to afford the corresponding chiral sulfoxide products with excellent optical purities. This reaction involves a dynamic kinetic resolution (DKR) process enabled by conformational locking and facile isomerization by chalcogen bonding interactions.
Nature Communications published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Related Products of amides-buliding-blocks.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics