Patel, Khushbu P. published the artcileGraphene Oxide: A Metal-Free Carbocatalyst for the Synthesis of Diverse Amides under Solvent-Free Conditions, Recommanded Product: N-Methylformamide, the main research area is amide preparation green chem solventless; amine carboxamide transamidation graphene oxide catalyst.
An environment-friendly, inexpensive, carbocatalyst, graphene oxide (GO) which promoted efficient, metal-free transamidation of various carboxamides RC(O)NH2 (R = Ph, pyridin-2-yl, H, Me, etc.) with aliphatic, cyclic, and aromatic amines NH(R1)(R2) [R1 = H, Ph; R2 = n-Bu, Ph, cyclohexyl, pyridin-2-yl, etc.; R1R2 = -(CH2)4-, -CH2CH2OCH2CH2-] and 2-aminothiophenol is demonstrated. The protocol is equally applicable to phthalimides such as 1H-isoindole-1,3(2H)-dione, 5-methyl-1H-isoindole-1,3(2H)-dione, ureas R3NHC(O)NH2 (R3 = H, Ph), and thioamide determining its adaptability. The oxygenated functionalities such as carbonyl (-C=O), epoxy (-O-), carboxyl (-COOH) and hydroxyl (-OH), present on graphene oxide surface impart acidic properties to the catalyst. The graphene oxide being heterogeneous in nature, work efficiently under solvent-free reaction conditions providing desired products RC(O)N(R1)(R2), I, R1NHC(O)NHR2 in good to excellent yields. The one-pot synthesis of 2,3-dihydro-5H-benzo[b]-1,4-thiazepin-4-one moiety by GO catalyzed Aza Michael addition followed by intramol. transamidation is also described. A plausible reaction mechanistic pathway involving H-bonding is discussed. The graphene oxide can be recycled and reused up to five cycles without much loss in catalytic activity.
Advanced Synthesis & Catalysis published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics