Iusupov, Ildar R. published the artcileDesign of gp120 HIV-1 entry inhibitors by scaffold hopping via isosteric replacements, Application In Synthesis of 343338-28-3, the main research area is HIV gp120 inhibitor preparation antiviral; Drug discovery; HIV; Lead optimization; Screening; Synthesis; gp120.
We present the development of alternative scaffolds and validation of their synthetic pathways as a tool for the exploration of new HIV gp120 inhibitors based on the recently discovered inhibitor of this class, NBD-14136. The new synthetic routes were based on isosteric replacements of the amine and acid precursors required for the synthesis of NBD-14136, guided by mol. modeling and chem. feasibility anal. To ensure that these synthetic tools and new scaffolds had the potential for further exploration, we eventually tested few representative compounds from each newly designed scaffold against the gp120 inhibition assay and cell viability assays.
European Journal of Medicinal Chemistry published new progress about Antiviral agents. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Application In Synthesis of 343338-28-3.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics