Li, Hanyuan published the artcileEnantiopure Chiral Phosphines Bearing a Sulfinyl Group and their Application in Catalytic Enantiodivergent Synthesis of Polysubstituted Pyrrolines, SDS of cas: 343338-28-3, the main research area is polysubstituted pyrroline enantiodivergent diastereoselective preparation; unsaturated imine allylic carbonate annulation enantiopure chiral phosphine catalyst.
In this work, a type of enantiopure chiral phosphines bearing a polar S=O sulfinyl group as the chiral unit in the mol. was developed, which could be prepared in either enantiomeric form from com. available materials by a three-step route. The enantiopure chiral phosphines could catalyze enantiodivergent asym. [4+1] annulation reactions of α,β-unsaturated imines and allylic carbonates, delivering polysubstituted pyrrolines I [R1 = C6H5, 4-FC6H4, 3-furyl, etc.; R2 = C6H5, 4-ClC6H4, 4-FC6H4, etc.] in either enantiomeric form in up to 99% yield and up to 99% ee, and thus empower a method for dual stereo-controlled synthesis of chiral pyrrolines. This work accordingly unveiled a practical and predictable strategy to realize enantiodivergent synthesis.
Advanced Synthesis & Catalysis published new progress about Carbonates Role: RCT (Reactant), RACT (Reactant or Reagent) (allylic). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, SDS of cas: 343338-28-3.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics