Borrego, Lorenzo G. published the artcileEnantioselective synthesis of 4-amino-3,4-dihydrocoumarins and their non-cyclic hydroxyester precursors: Biological evaluation for the treatment of glioblastoma multiforme, Computed Properties of 343338-28-3, the main research area is amino dihydrocoumarin preparation enantioselective antitumor; Enantiopure 4-amino-3,4-dihydrocoumarins; Glioblastoma multiforme; N-sulfinylarylimines; β-hydroxyesters.
The stereoselective addition of Et acetate enolate to the CN bond of N-tert-butylsulfinylimines was investigated in depth. A significant effect of the LHMDS amount and the N-sulfinylimine nature on the stereoselectivity of the process was observed Conditions were found where sulfinylimines of differently substituted salicylaldehydes derivatives, Et acetate, and LHMDS afforded the corresponding addition products as a single diastereomer in good yields. The developed protocol was successfully applied to the first stereoselective synthesis of differently substituted 4-amino-3,4-dihydrocoumarin derivatives Computational models confirmed the prominent role of the ortho aryl substituent in the stereoselectivity of the process. A significant and selective cytotoxic activity against Glioblastoma Multiforme (GBM) cancer line has been determined for the noncyclic hydroxy ester derivative
European Journal of Medicinal Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Computed Properties of 343338-28-3.
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