Raubo, Piotr published the artcileThe discovery and evaluation of 3-amino-2(1H)-pyrazinones as a novel series of selective p38α MAP kinase inhibitors, Application of (S)-2-Methylpropane-2-sulfinamide, the main research area is amino pyrazinone derivative preparation p38MAP kinase inhibitor inhalation structure; AZD6703; AZD7624; COPD; Inflammation; Kinases; P38α.
The discovery and optimization of a novel series of potent and selective p38α inhibitors is described. Evaluating the structure-activity relationship of an aminoalkyl substituent at the 3 position of the 2(1H)-pyrazinone core, p38α potency was increased 20000-fold. The most advanced compound (25) demonstrated excellent in vivo properties suitable for an inhaled route of administration.
Bioorganic & Medicinal Chemistry Letters published new progress about Anti-inflammatory agents. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Application of (S)-2-Methylpropane-2-sulfinamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics