Zayas-Gonzalez, Yashira M. published the artcileDegradable Amine-Reactive Coatings Fabricated by the Covalent Layer-by-Layer Assembly of Poly(2-vinyl-4,4-dimethylazlactone) with Degradable Polyamine Building Blocks, SDS of cas: 10405-38-6, the main research area is amine reactive coating fabricated covalent assembly polyvinyldimethylazlactone polyamine.
We report the fabrication of reactive and degradable crosslinked polymer multilayers by the reactive/covalent layer-by-layer assembly of a non-degradable azlactone-functionalized polymer [poly(2-vinyl-4,4-dimethylazlactone), PVDMA] with hydrolytically or enzymically degradable polyamine building blocks. Fabrication of multilayers using PVDMA and a hydrolytically degradable poly(β-amino ester) (PBAE) containing primary amine side chains yielded multilayers (∼100 nm thick) that degraded over ∼12 days in physiol. relevant media. Physicochem. characterization and studies on stable films fabricated using PVDMA and an analogous non-degradable poly(amidoamine) suggested that erosion occurred by chem. hydrolysis of backbone esters in the PBAE components of these assemblies. These degradable assemblies also contained residual amine-reactive azlactone functionality that could be used to impart new functionality to the coatings post-fabrication. Crosslinked multilayers fabricated using PVDMA and the enzymically degradable polymer poly(L-lysine) were structurally stable for prolonged periods in physiol. media, but degraded over ∼24 h when the enzyme trypsin was added. Past studies demonstrate that multilayers fabricated using PVDMA and non-degradable polyamines [e.g., poly(ethyleneimine)] enable the design and patterning of useful nano/bio-interfaces and other materials that are structurally stable in physiol. media. The introduction of degradable functionality into PVDMA-based multilayers creates opportunities to exploit the reactivity of azlactone groups for the design of reactive materials and functional coatings that degrade or erode in environments that are relevant in biomedical, biotechnol., and environmental contexts. This ‘degradable building block’ strategy should be general; we anticipate that this approach can also be extended to design of amine-reactive multilayers that degrade upon exposure to specific chem. triggers, selective enzymes, or contact with cells by judicious design of the degradable polyamine building blocks used to fabricate the coatings.
Biomacromolecules published new progress about Coating materials. 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, SDS of cas: 10405-38-6.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics