Boskovic, Zarko V. published the artcileSynthesis of piperlogs and analysis of their effects on cells, Related Products of amides-buliding-blocks, the main research area is piperlog preparation antitumor structure activity; reactive oxygen species level piperlog; piperlongumine analog preparation antitumor structure activity; Michael acceptors; piperlongumine; reactive oxygen species; toxicity.
Piperlongumine (PL) (I) is a naturally occurring small mol. previously shown to induce cell death preferentially in cancer cells relative to non-cancer cells. An initial effort to synthesize analogs highlighted the reactivities of both of piperlongumine’s α,β-unsaturated imide functionalities as key features determining PL’s cellular effects. In this study, a second-generation of analogs, e.g., II, was synthesized and evaluated in cells to gain further insight into how the reactivity, number, and orientation of PL’s reactive olefins contribute to its ability to alter the physiol. of cells.
Tetrahedron published new progress about Antitumor agents. 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, Related Products of amides-buliding-blocks.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics