Mayhoub, Abdelrahman S. published the artcileAn investigation of phenylthiazole antiflaviviral agents, COA of Formula: C11H15NS, the main research area is antiflaviviral phenylthiazole preparation SAR.
Flaviviruses are one of the most clin. important pathogens and their infection rates are increasing steadily. The phenylthiazole ring system has provided a template for the design and synthesis of antiviral agents that inhibit the flaviviruses by targeting their E-protein. Unfortunately, there is a correlation between phenylthiazole antiflaviviral activity and the presence of the reactive and therefore potentially toxic mono- or dibromomethyl moieties at thiazole-C4. Adding a linear hydrophobic tail para to the Ph ring led to a new class of phenylthiazole antiflaviviral compounds that lack the toxic dibromomethyl moiety. This led to development of a drug-like phenylthiazole 12 (I) that had high antiflaviviral selectivity (TI = 147).
Bioorganic & Medicinal Chemistry published new progress about Antiviral agents. 1208077-46-6 belongs to class amides-buliding-blocks, name is 4-Butylthiobenzamide, and the molecular formula is C11H15NS, COA of Formula: C11H15NS.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics