Electric Literature of 148017-28-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 148017-28-1 as follows.
Example 82: N-[((lR,2R,3S,4R)-4-{6-[(lS)-2,3-dihydro-lH-inden-l-ylamino]-9H-purin-9-yl}- 2,3-dihydroxycyclopentyl)methyl]sulfamide (1-87)Step a: fert-Butyl (aminosulfonyl){r(3aR,4R>6R,6aS)-6-(6-chloro-9H-purin-9-yl)-2,2- dimethyltetrahydro-SaH-cyclopentardiri^ldioxoM-ynmethyllcarbamate; [0614] To a solution of ((3aR,4R,6i?,6aS)- [6-(6-chloro-purin-9-yl)-2,2-dimethyl- tetrahydro-cyclopenta[l,3]dioxol-4-yl]-methanol (Yang, M.; Wei, Y.; Schneller, S. W. /. Org. Chem. 2004, 69, 3993-3996) (250.0 mg, 0.77 mmol), N-Boc-sulfonamide (226.6 mg, 1.16 mmol) and triphenylphosphine (242.3 mg, 0.92 mol) in EtOAc (8 mL) was added diisopropyl azodicarboxylate (227.3 muL, 1.16 mmol) dropwise as a solution in EtOAc (1 mL). The reaction was stirred at r.t. overnight, quenched with water and extracted with EtOAc. The organics were concentrated and the residue purified by flash chromatography (0 to 100% EtOAc/DCM) to obtain the product as an inseparable mixture with triphenylphosphine oxide. The material was carried on as such.[0615] LCMS: Rt. 2.49 min ES+ 503 (formic acid).
According to the analysis of related databases, 148017-28-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; WO2006/84281; (2006); A1;,
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