Okolo, ChrisTina published the artcileHexafluoroisopropanol-Mediated Domino Reaction for the Synthesis of Thiazolo-androstenones: Potent Anticancer Agents, Application of 3-Methoxybenzothioamide, the publication is ACS Omega (2018), 3(12), 17991-18001, database is CAplus and MEDLINE.
A cascade reaction of thioamides with 6-bromoandrostenedione in hexafluoroisopropanol formed substituted thiazolo-androstenones. This is a simple and mild protocol to synthesize novel mols. by using readily available reagents and substrates. Feasibility of the reaction has been rationalized by d. functional theory (DFT) calculations Moreover, these compounds are potent growth inhibitors of colon, central nervous system (CNS), melanoma, ovarian, and renal cancer cell lines with 50% growth inhibition (GI50) values as low as 1.04 μM.
ACS Omega published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, Application of 3-Methoxybenzothioamide.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics