Remen, Lubos published the artcilePreparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T-Type Calcium Channel Blockers, Category: amides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2016), 59(18), 8398-8411, database is CAplus and MEDLINE.
Aryldihydropyrazolecarboxamides such as I were prepared as brain-penetrating T-type calcium channel blockers for potential use as antiepileptic agents; their inhibition of T-type calcium channels over related calcium channels responsible for potential cardiovascular side effects was determined I was advanced to in vivo studies, where it demonstrated efficacy in the WAG/Rij rat model of generalized nonconvulsive, absence-like epilepsy. I was not efficacious in the basolateral amygdala kindling rat model of temporal lobe epilepsy, and it led to prolongation of the PR interval in ECG recordings in rodents.
Journal of Medicinal Chemistry published new progress about 100377-32-0. 100377-32-0 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N-Methoxy-N-methylisonicotinamide, and the molecular formula is C8H10N2O2, Category: amides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics