Tambe, Suparna published the artcileStructure-performance relationships of phenyl cinnamic acid derivatives as MALDI-MS matrices for sulfatide detection, Related Products of amides-buliding-blocks, the publication is Analytical and Bioanalytical Chemistry (2017), 409(6), 1569-1580, database is CAplus and MEDLINE.
A key aspect for the further development of matrix-assisted laser desorption ionization (MALDI)-mass spectrometry (MS) is a better understanding of the working principles of MALDI matrixes. To address this issue, a chem. compound library of 59 structurally related cinnamic acid derivatives was synthesized. Potential MALDI matrixes were evaluated with sulfatides, a class of anionic lipids which are abundant in complex brain lipid mixtures For each matrix relative mean S/N ratios of sulfatides were determined against 9-aminoacridine as a reference matrix using neg. ion mass spectrometry with 355 and 337 nm laser systems. The comparison of matrix features with their corresponding relative mean S/N ratios for sulfatide detection identified correlations between matrix substitution patterns, their chem. functionality, and their MALDI-MS performance. Crystal structures of six selected matrixes provided structural insight in hydrogen bond interactions in the solid state. Principal component anal. allowed the addnl. identification of correlation trends between structural and phys. matrix properties like number of exchangeable protons at the head group, MW, logP, UV-Vis, and sulfatide detection sensitivity.
Analytical and Bioanalytical Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C7H5I2NO3, Related Products of amides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics