Gless, Bengt H. published the artcileIdentification of autoinducing thiodepsipeptides from staphylococci enabled by native chemical ligation, Name: H-Lys(Boc)-OH, the publication is Nature Chemistry (2019), 11(5), 463-469, database is CAplus and MEDLINE.
Staphylococci secrete autoinducing peptides (AIPs) as signaling mols. to regulate population-wide behavior. AIPs from non-Staphylococcusaureus staphylococci have received attention as potential antivirulence agents to inhibit quorum sensing and virulence gene expression in the human pathogen Staphylococcus aureus. However, only a limited number of AIP structures from non-S. aureus staphylococci have been identified to date, as the minute amounts secreted in complex media render it difficult. Here, we report a method for the identification of AIPs by exploiting their thiolactone functionality for chemoselective trapping and enrichment of the compounds from the bacterial supernatant. Standard liquid chromatog. mass spectrometry anal., guided by genome sequencing data, then readily provides the AIP identities. Using this approach, we confirm the identity of five known AIPs and identify the AIPs of eleven non-S. aureus species, and we expect that the method should be extendable to AIP-expressing Gram-pos. bacteria beyond the Staphylococcus genus.
Nature Chemistry published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C11H22N2O4, Name: H-Lys(Boc)-OH.
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