Epsztajn, Jan published the artcileApplications of organolithium and related reagents in synthesis. Part 4. A general study of the reactions of N,N-dialkylpyridinecarboxamides with lithium diisopropylamide, Safety of N,N-Diethylisonicotinamide, the publication is Journal of Chemical Research, Synopses (1986), 18-19, database is CAplus.
Treatment of N,N-diisopropylpyridinecarboxamides with (Me2CH)2NLi (I) gave the corresponding lithiated amides regioselectively and reversibly. The lithiated amides were stable at -78°, but underwent self-addition to the parent compounds at higher temperatures and underwent trapping by a variety of carbonyl electrophiles to give a range of substituted products. E.g., treatment of N,N-diisopropylnicotinamide with I in Et2O-C6H6 at -78° for 1 h, followed by addition of BzNMe2 and stirring 2 h, gave 73% 4-benzoyl-N,N-diisopropylnicotinamide.
Journal of Chemical Research, Synopses published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Safety of N,N-Diethylisonicotinamide.
Referemce:
https://en.wikipedia.org/wiki/Amide,
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