Li, Ze-lin published the artcilePd/Ni catalyzed selective N-H/C-H methylation of amides by using peroxides as the methylating reagents via a radical process, COA of Formula: C7H8FNO2S, the publication is Organic Chemistry Frontiers (2017), 4(11), 2207-2210, database is CAplus.
A palladium/nickel catalyzed selective N-H/C-H methylation of amides such as benzenesulfonamide, nicotinamide, benzamide, etc. by using peroxides to provide N-methylation products such as N-methylbenzenesulfonamide, N-methylnicotinamide, N-methylbenzamide, etc. and C-methylation products such as 2-methylbenzenesulfonamide, 2-methylnicotinamide, 2-methylbenzamide, etc. in moderate to good yields was described. In this procedure, peroxides play a dual role, serving as both the Me source and radical initiator. This protocol tolerated a broad range of substrates, not only various sulfonamides but also methanamides. Mechanistic investigations involving a radical process are also described.
Organic Chemistry Frontiers published new progress about 489-17-8. 489-17-8 belongs to amides-buliding-blocks, auxiliary class Fluoride,Sulfamide,Amine,Benzene, name is 4-Fluoro-2-methylbenzenesulfonamide, and the molecular formula is C7H8FNO2S, COA of Formula: C7H8FNO2S.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics