Anti-inflammatory and Quinone Reductase-Inducing Compounds from Beilschmiedia mannii was written by Ahoua, Angora Remi Constant;Monteillier, Aymeric;Borlat, Frederic;Ciclet, Olivier;Marcourt, Laurence;Nejad Ebrahimi, Samad;Kone, Mamidou Witabouna;Bonfoh, Bassirou;Christen, Philippe;Cuendet, Muriel. And the article was included in Planta Medica in 2019.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:
Previous studies on the therapeutic potential of plant species found in the diet of chimpanzees living in tai national park have shown that they could be potential candidates for the search of new mols. useful for humans. Based on the screening of some of these plants, the fruits of beilschmiedia mannii, whose dichloromethane extract showed cancer chemopreventive properties, were selected. Bioactivity-guided fractionation of the extract resulted in the isolation and identification of two pyrones, including desmethoxydihydromethysticin ( 1), found in a natural source for the first time, and a new congener, beilschmiediapyrone ( 2), as well as five known alkamides ( 3 – 7). Their structures were established by using nmr spectroscopy and mass spectrometry methods. The isolated compounds were evaluated for their cancer chemopreventive potential by using quinone reductase induction and nuclear factor-kappa b inhibition tests in hepa 1c1c7 and hek-293/nf- b-luc cells, resp. Among them, compounds 1and 2were the most active. The concentrations to double the quinone reductase activity were 7.5 mum for compound 1and 6.1 mum for compound 2. Compounds 1and 2inhibited nuclear factor-kappa b with ic 50values of 2.1 and 3.4 mum, resp. These results are promising with regard to cancer chemoprevention, especially because this plant is also used for cooking by the local population around the tai forest. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide).
(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics