Quantitative in vitro and in vivo evaluation of intestinal and blood-brain barrier transport kinetics of the plant N-alkylamide pellitorine was written by Veryser, Lieselotte;Bracke, Nathalie;Wynendaele, Evelien;Joshi, Tanmayee;Tatke, Pratima;Taevernier, Lien;De Spiegeleer, Bart. And the article was included in BioMed Research International in 2016.Related Products of 18836-52-7 The following contents are mentioned in the article:
Objective: To evaluate the gut mucosa and blood-brain barrier (BBB) pharmacokinetic permeability properties of the plant Nalkylamide pellitorine. Methods: Pure pellitorine and an Anacyclus pyrethrum extract were used to investigate the permeation of pellitorine through (1) a Caco-2 cell monolayer, (2) the rat gut after oral administration, and (3) the BBB in mice after i.v. and intracerebroventricular administration. A validated bioanal. UPLC-MS2 methodwas used to quantify pellitorine. Results: Pellitorine was able to cross the Caco-2 cell monolayer from the apical-to-basolateral and from the basolateral-to-apical side with apparent permeability coefficients between 0.6 · 10^^-^^5 and 4.8 · 10^^-^^5 cm/h and between 0.3 · 10^^-^^5 and 5.8 · 10^^-^^5 cm/h, resp. In rats, a serum elimination rate constant of 0.3 h^^-^^1 was obtained. I.v. injection of pellitorine in mice resulted in a rapid and high permeation of pellitorine through the BBB with a unidirectional influx rate constant of 153μL/(g·min). In particular, 97% of pellitorine reached the brain tissue, while only 3% remained in the brain capillaries. An efflux transfer constant of 0.05 min-1 was obtained. Conclusion: Pellitorine shows a good gut permeation and rapidly permeates the BBB once in the blood, indicating a possible role in the treatment of central nervous system diseases. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Related Products of 18836-52-7).
(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Related Products of 18836-52-7
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics