Wang, Xiaojuan published the artcileCollecting the Molecular and Ionization States of Irbesartan in the Solid State, Computed Properties of 1453-82-3, the publication is Crystal Growth & Design (2020), 20(9), 5664-5669, database is CAplus.
An active pharmaceutical ingredient may exist in different solid forms, which are the products of the variation of mol. conformation and packing order stabilized through different intermol. interactions. Two special conditions, tautomerism and amphoterism, will make the solid-state landscape more abundant and diverse. Two known polymorphs of irbesartan (IBS) contain mols. in different tautomeric forms, resp. Here, one cationic salt and one anionic salt of IBS were successfully harvested. The NMR spectra demonstrated clear fingerprint features for these four different mol. and ionization states of IBS. The newly obtained crystalline forms also provide much better dissolution performance. Irbesartan can exist in 1H-tautomeric, 2H-tautomeric, cationic, and anionic states in different crystalline samples.
Crystal Growth & Design published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H12Br2, Computed Properties of 1453-82-3.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics