Piper longum Linn.-a fruit contains potential inhibitors of COVID-19 main protease based on molecular docking was written by Sivaraj, S.;Rangaraj, S.;Suguna, A.. And the article was included in World Journal of Pharmaceutical Research in 2020.Formula: C14H25NO The following contents are mentioned in the article:
A new coronavirus (nCoV) identified as the etiol. agent responsible for the 2019-2020 viral pneumonia outbreak that commenced in Wuhan. Currently there is no clin. approved antiviral drug or vaccine available and effective treatment options remain very limited. Here, we have studied the virtual interaction between COVID-19 main protease (Mpro-PDB ID: 6LU7) and ten bioactive compounds of Piper longum by mol. docking using Autodock 4.2. It was identified that Piperundecalidine, a phytoconstituent present in fruit of Piper longum as potential inhibitor of COVID-19 Mpro which shows higher binding affinity (-9.54 kcal/mol) than the lead tideglusib (-8.48 kcal/mol). However, these data need further in vitro and in vivo evaluation to use against 2019-nCoV. This was the first report on phytoconstituents of Piper longum as potential inhibitor of COVID-19 Mpro using mol. docking studies. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Formula: C14H25NO).
(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Formula: C14H25NO
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics