Insecticidal activity of isobutylamides derived from Piper nigrum against adult of two mosquito species, Culex pipiens pallens and Aedes aegypti was written by Park, Il-Kwon. And the article was included in Natural Product Research in 2012.Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:
The insecticidal activity of Piper nigrum fruit-derived piperidine alkaloid (piperine) and N-isobutylamide alkaloids (pellitorine, guineensine, pipercide and retrofractamide A) against female adults of Culex pipiens pallens and Aedes aegypti was examined On the basis of 24-h LD50 values, the compound most toxic to female C. pipiens pallens was pellitorine (0.4 μg/female) followed by guineensine (1.9 μgfemale/), retrofractamide A (2.4 μg/female) and pipercide (3.2 μg/female). LD50 value of chlorpyrifos was 0.03 μg/female. Against female A. aegypti, the insecticidal activity was more pronounced in pellitorine (0.17 μg/) than in retrofractamide A (1.5 μg/female), guineensine (1.7 μg/female), and pipercide (2.0 μg/female). LD50 value of chlorpyrifos was 0.0014 μg/female. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide).
(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Safety of (2E,4E)-N-Isobutyldeca-2,4-dienamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics